Botanical Index No. 558

Jaborandi

pilocarpus spp

Safety & Contraindications

Class 2b. “Hazards and/or side effects not known for proper therapeutic dosages”. Not for use during pregnancy. The lethal dose of pilocarpine is ca 60 mg, corresponding to 5–10 g drug. My database suggests that it is much less toxic; LD50 pilocarpine = 911 mg/kg orl rat. Poisoning possible through eye drops being swallowed through eye or nose. May cause bradycardia, bronchial cramps, colic, convulsion, diaphoresis, dyspnea, emesis, hypotension, and salivation.

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