Botanical Index No. 295

Conessi, Kurchi

holarrhena pubescens

Medicinal Actions

Colic

Primary Conditions Treated

Ameba Amebiasis Anorexia Asthma Bite Bleeding Boil Bronchosis Cancer Cholera Constipation Cramp Dermatosis Diabetes Diarrhea Dropsy Dysentery Dysmenorrhea Dyspepsia Dysuria Epilepsy Epistaxis Erysipelas Fatigue Fever Gas Gingivosis Headache Hematuria Hemorrhoid High Blood Pressure Hyperglycemia Infertility Inflammation Jaundice Leprosy Leukoderma Lumbago Malaria Menorrhagia Myalgia Pain Parturition Pulmonosis Rhinosis Snakebite Sore Splenosis Spermatorrhea Stomachache Trichomoniasis Toothache Trypanosoma Tuberculosis Urethrosis Virus Water Retention Worm

General Dosage

2–4 g powdered seed; 28–74 ml decoction or tea; 2–4 ml tincture; daily dose of 60–120 grains powdered bark in 3–4 portions; bark taken in decoction; doses >500 mg/person may be toxic.

Safety & Contraindications

Not covered. Doses of conessine >500 mg day may induce GI distress, insomnia, restlessness, tremors, vertigo, possibly even death from central respiratory paralysis. LD50 = 250 mg/kg ipr mouse. LD50 = 1000 mg/kg ipr mouse. With at least 18 alkaloids, is the conessine most important at 4000 ppm. Conessine increases coronary outflow in isolated animal tissues. Induces narcosis in frogs and is locally anesthetic in guinea pigs, being “twice as active as cocaine.” Subcutaneous injections may induce necrosis. Conessine has antiamebic activities comparable to emetine.

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